It inhibits the production of hemoglobin and red blood cells. More severe forms of thalassemia often require frequent blood transfusions, possibly every few weeks. The signs and symptoms you experience depend on the type and severity of your condition. A person may have alpha or beta thalassemia, and symptoms … Thalassemia minor generally doesn’t cause any symptoms. Other people have mild to severe symptoms. General Symptoms of Thalassemia. Symptoms of thalassemia. A person may have either alpha thalassemia trait or beta thalassemia trait, depending upon which form of … What if one parent has alpha thalassemia trait and the other parent is a silent carrier? If one parent has the cis form of alpha thalassemia trait (αα/--), and the other parent is a silent carrier (αα/α-), there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin H disease. People who have thalassemia trait (also called thalassemia minor) carry the genetic trait for thalassemia but do not suffer from any health problems except a mild anemia. Alpha Thalassemia Minor, also called Alpha Thalassemia Trait (2 genes affected). Thalassemia is an inherited blood disorder. It leads to a decrease in overall hemoglobin levels, with the characteristic signs and symptoms of anemia.. Signs and symptoms of alpha thalassemia are those of other types of anemia and include. Beta Thalassemia trait: Introduction. Some people have little or even no symptoms. Some such cases result from an autosomal dominant form of thalassemia and others from inheriting a mutation that is not detected by the probes utilized in the DNA testing. Some babies show signs and symptoms of thalassemia at birth, while others may develop them during the first two years of life. Beta-thalassemia. Intermediate forms of thalassemia can cause mild to moderate anemia and may be associated with other health problems such as slowed growth, delayed puberty, bone … What are the Symptoms of Thalassemia? Learn more about thalassemia, also known as Mediterranean Anemia, Cooley's Anemia or Homozygous Beta Thalassemia, and possible signs, symptoms, and treatment options for both thalassemia trait and tha The signs and symptoms vary depending on the severity of the thalassemia. Tiredness, low energy, or muscle weakness (also called fatigue). Hemoglobin E/thalassemia: common in Cambodia, Thailand, and parts of India, it is clinically similar to β thalassemia major or thalassemia intermedia. For moderate to severe thalassemia, treatments might include: Frequent blood transfusions. Thalassemia minor. [ citation needed ] Hemoglobin S /thalassemia: common in African and Mediterranean populations, is clinically similar to sickle-cell anemia , with the additional feature of splenomegaly . Symptoms of thalassemia may include one or more of the following: Paleness. People who have alpha thalassemia trait have red blood cells that are smaller (microcytic) and paler (hypochromic) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size of a single red blood cell), and have a mild chronic anemia. Mild forms of thalassemia trait don't need treatment. This is why it is also sometimes referred to as Mediterranean anemia. Beta Thalassemia trait: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. If it does, it causes minor anemia. For example, people affected by milder forms of thalassemia can develop mild anemia or may have no signs or symptoms of the condition at all. There are two subtypes of the disorder (alpha and beta) depending on what portion of the hemoglobin is abnormally synthesized. 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