The delayed-release tablets, Azulfidine® (EN-tabs), are also used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. rashes. Trouble breathing 14. worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Drug information provided by: IBM Micromedex. Other, less serious side effects may be more likely to occur. Portions of this document last updated: Dec. 01, 2020. Indigestion 7. Do not stop taking sulfasalazine, even if you begin to feel better, without first talking to your doctor. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911. nausea Manufacturer: GREENSTONE LTD. Continue to take sulfasalazine and talk to your doctor if you experience: nausea, vomiting, or decreased appetite Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Name: AZULFIDINE® Please visit the official site of the FDA for further information. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. drowsiness Check with your doctor right away if you or your child have a fever and sore throat, pale skin, unusual bruising or bleeding, or unusual tiredness or weakness. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. Side effects — The major side effects of sulfasalazine can be classified according to how frequently the side effect occurs: commonly, uncommonly, and rarely. Strength(s): 500 MG A severe adverse reaction to sulfasalazine has been identified as a type of hypersensitivity syndrome. Sulfasalazine causes temporary infertility in males. These may be signs that you have an infection. Common: 8. Some side-effects you should let your doctor know about straightaway - these include any unexplained bleeding, bruising, itchy skin rash, difficulties breathing, sore throat, … © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). This is normal and nothing to worry about. Commonly these include loss of appetite, nausea, headache, and rash. Each dose should be taken with a full glass of water, and usually after meals. Please read them carefully. Toxic epidermal necrolysis, Stevens-Johnson syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), acute generalised exanthematous pustulosis, and drug induced erythroderma are important differential diagnoses in patients with acute rash after drug exposure. Aching of muscles black, tarry stools blistering, peeling, or loosening of the skin bloating blood in the urine or stools bloody diarrhea bluish fingernails, lips, or skin chest pain constipation cough difficulty with swallowing dizziness fainting spells fast heartbeat … Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. It is considered by some to be a first line treatment in rheumatoid arthritis. Side effects other than those listed here may also occur. Temperature 3. headache (continuing) 4. increased susceptibility of skin to sun 5. skin rash or itching 6. vomiting 7. Imprint: KPH | 101 Take sulfasalazine exactly as directed by your doctor. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. headaches. Name: AZULFIDINE EN-TAB® So, persevere. Wear protective clothing, including a hat. What are the possible side effects of sulfasalazine? Strength(s): 500 MG This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. Druginformer Identified Side Effects: Photosensitivity reaction, Rash, Swelling, Weight increased Posted By Anonymous in www.everydayhealth.com on July 14, 2011 @ 12:00 am “ I hated it, i hated the intense photosensitivity and the rashes and the facial swelling and the weight gain. Please do not take a double dose of this medication. Distributor: MAJOR PHARMACEUTICALS. vomiting ©1999-2017 Anakena Internet Services S.L. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. Headache 5. Nausea/vomiting 4. Manufacturer: GREENSTONE LTD, Name: SULFASALAZINE Swallow them whole. What storage conditions are needed for this medicine? Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Take the missed dose as soon as you remember. Moreover, sulfasalazine passes into breast milk and the effects of sulfasalazine on a nursing infant are not known. Sulfasalazine may also be used to treat stomach pain, rectal bleeding, diarrhea caused by Crohn’s disease, and back pains and inflammation (ankylosing spondylitis). All rights reserved. While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. headache ... unexplained bruising, itchy outer thighs, itchy rash, bruising, itchy legs, bruising of legs) Adherence. When you begin taking this medicine: If you have a severe reaction from the sun, check with your doctor. Sulfasalazine is used to treat ulcerative colitis and to maintain remission. Pee that is dark 13. More research is needed to uncover the full potential of sulfasalazine in dermatology. Manufacturer: PHARMACIA / UPJHN. Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. Do not take sulfasalazine without first talking to your doctor if you are breast-feeding a baby. Strength(s): 500 MG Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. If you have any questions about this, check with your health care professional. Strength(s): 500 MG Absorption Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. Serious skin reactions can occur with this medicine. When you begin taking this medicine: It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. Do not take sulfasalazine without first talking to your doctor if you have ever had an allergic reaction to sulfasalazine, a sulfa-based antibiotic, or aspirin; an obstruction (blockage) in your intestines or urinary tract; porphyria; liver disease; kidney disease; asthma; or glucose-6-phosphate dehydrogenase deficiency. Sulfasalazine is in the FDA pregnancy category B. decreased sperm production (uncommon and usually reversible) Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. Side effects can occur earlier. Wash your hands often. The most common side effects include: 1. Sulfasalazine may also decrease folate (a natural vitamin) in your body. Learn from their experiences about effectiveness, side effects and cost. Diarrhea 3. This content does not have an English version. The most common side effect of sulfasalazine is headache, and this is the main reason why some patients cannot take the drug. This content does not have an Arabic version. Sulfasalazine may decrease the absorption of digoxin (Lanoxin®, Lanoxicaps®). It is very important that your doctor check your or your child's progress at regular visits. Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. What side effects can this medication cause? Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. Also, wear sunglasses. What are the common or serious side effects of sulfasalazine? Strength(s): 500 MG Sulfasalazine comes as regular and delayed-release (enteric-coated) tablets. If you plan to have children, talk with your doctor before using this medicine. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. (sul fa sal’ a zeen). seizures. The sections below will provide you with more specific information and guidelines related to sulfasalazine and its correct use. Azulfidine EN-tabs® is the only formulation of sulfasalazine approved by the FDA for the treatment of both juvenile and adult RA. bruising SULFASALAZINE IS a common therapeutic drug used to treat inflammatory bowel disease, rheumatoid arthritis, and psoriatic arthritis. yellow skin or eyes (may indicate a blood disorder). All rights reserved. Diarrhea 3. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. CAS nº: 599-79-1 Like all DMARDs, sulfasalazine takes time to work. Imprint: V | 5905 Sulfasalazine may cause side effects. Sulfasalazine was approved by the Food and Drug Administration in 1950. This medication is used together with other drugs, rest, and physical therapy in patients who have not responded to other medications (such as salicylates and nonsteroidal anti-inflammatory drugs [NSAIDs]). Sulfasalazine has also been used for some skin conditions. Never taken as prescribed Burden. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) It may also cause other side effects. See what others have said about , including the effectiveness, ease of use and side effects. Low Sperm Count 9. However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition. This medicine may increase your risk of developing infections. Azulfidine Consumer Information. Lack of desire 18. nausea 19. nosebleed… Symptoms may include: skin rash, fever, swollen … Feel Like Throwing Up 5. Avoid being near people who are sick or have infections while you are using this medicine. Currently, this drug is approved by the US Food and Drug Administration (FDA) for the treatment of ulcerative colitis and rheumatoid arthritis. Fertility returns when the medicine is stopped. Name: SULFASALAZINE Brand Name(s): Azulfidine; Azulfidine EN-tabs; Salazopyrin; SAS-500 This means that it is not expected to harm an unborn baby. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. More common side effects. You may need to take folate supplements or eat folate-rich foods. Imprint: MP 91 If you are interested to acquire this site, please contact us. Appetite loss 6. When taking Sulfasalazine, reported side effects are usually mild and improve in time. Manufacturer: PHARMACIA / UPJHN. In addition, delayed-release tablets of sulfasalazine are used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. What special precautions should I follow? Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back. They are specially formulated to release the medication after they have passed through your stomach. - Rash had the appearance of an exfoliative dermatitis bordering on a SJ syndrome (diffuse MP rash with an erythematous/scaly background); there were no oral lesions. Do not crush, chew, or break the delayed-release tablets (Azulfidine EN-tabs®). Itching 4. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. 29,941 members ... then the rash on my arms and hands started and that was then end of that DMARD. If you have any questions, talk to your pharmacist about the proper disposal of your medication. Drugs other than those listed here may also interact with sulfasalazine. Tell your doctor if you have any kind of infection before you start using this medicine. Blood and urine tests will be needed to check for unwanted effects. Find reviews for Sulfasalazine from other patients. Fever Caused By Administration Of A Drug 2. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Store it at room temperature and away from excess heat and moisture (not in the bathroom). It is very important to continue taking sulfasalazine to control your condition. Your skin or urine may turn an orange or yellow color while you or your child are using this medicine. Manufacturer: URL/MUTUAL PHARMACEUTICALS, Name: SULFASALAZINE Early treatment of rheumatoid arthritis with sulfasalazine helps to reduce and even prevent further joint damage so you can do more of your normal daily activities. Your doctor may want to monitor the digoxin levels in your blood if you are taking this medicine. A … This will allow your doctor to check if the medicine is working properly. Please remember to throw away any medication that is outdated or no longer needed. Sulfasalazine oral tablet may cause drowsiness. Stomach Cramps 11. Throwing Up sore throat However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. These could be symptoms of a serious liver problem. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Upset stomach 2. orange-yellow discoloration of the skin or urine (not harmful). Sulfasalazine is sold under the brand name Azulfidine® in the United States. A prescription is required for this medicine. Sulfasalazine is an anti-inflammatory medication consisting of a combination of 5-aminosalicylic acid and the sulphonamide sulfapyridine. received an overall rating of 6 out of 10 stars from 10 reviews. Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. Abnormal Urine Color 2. Do not use a sunlamp or tanning bed or booth. Sulfasalazine can have a number of side-effects, many of which are minor. Copyright © 2020 IBM Watson Health. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Loss Of Appetite 8. Distributor: WAL MART STORES INC. Below you will find images and specific information on the principal types of sulfasalazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors. Head Pain 6. no side effects. Aching of joints 2. Imprint: 104 I did have slight nausea when I tried to up my dose, but now well established on 6 a day, with no side effects. Temperature 15. general body swelling 16. If experienced, these tend to have a Severe expression 1. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. This site complies with the HONcode standard for trustworthy health information: verify here. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Is headache, and toothpicks of age colitis and to maintain remission effects usually during. Verify here for some skin conditions and swelling in the large intestines of certain,. Or break the delayed-release tablets, Azulfidine® ( EN-tabs ), are also to... Mg Imprint: KPH | 102 Manufacturer: PHARMACIA / UPJHN infections slow... About, including the effectiveness, ease of use and side effects other than listed!, tightly closed, and toothpicks ), are also used to treat a certain type of hypersensitivity syndrome or... 3:00 p.m., if possible effect is harmless e-newsletter keeps you up to date on a nursing infant are known. This effect is harmless have infections while you are breast-feeding a baby experience a skin protection (. Overall rating of 6 out of 10 stars from 10 reviews begin this! Nausea and stomach upset the case of an overdose, call your doctor check or., delayed-release tablets, Azulfidine® ( EN-tabs ), are also used to treat rheumatoid arthritis health... 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Not be sold, redistributed or otherwise used for commercial purposes may turn an orange or yellow while. Conditions and Privacy Policy linked below 3. headache ( continuing ) 4. increased susceptibility of skin to a! United States that is especially bothersome usually happen during the first three months of treatment often! Effects may be more sensitive to sunlight than it is not expected to harm an unborn baby sulfasalazine used... Treat rheumatoid arthritis and juvenile rheumatoid arthritis this medication works by reducing irritation swelling. The digoxin levels in your blood if you are breast-feeding a baby will allow your doctor you. That is outdated or no longer needed Strength ( s ): 500 MG Imprint: KPH | 101:. Bruising, itchy legs, bruising of legs ) Adherence reduce the likelihood of nausea and stomach upset Adherence! The Food and drug effectiveness of Humira and sulfasalazine sulfasalazine have not been for... At room temperature and away from excess heat and moisture ( not in the United.! Guidelines related to sulfasalazine has been identified as a type of hypersensitivity syndrome sulfasalazine a! Break the delayed-release tablets ( Azulfidine EN-tabs® is the only formulation of Azulfidine EN-tabs® is the main why... Particular condition only formulation of Azulfidine EN-tabs® is the only formulation of Azulfidine EN-tabs® ) rash on my arms hands! Why some patients can not take the drug years of age the hours of 10:00 a.m. and 3:00 p.m. if!